Cisplatin liver toxicity
WebApr 5, 2024 · Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, cisplatin also causes cytoplasmic organelle dysfunction particularly with … WebOct 5, 2014 · Oxidative stress is the one of most important mechanisms involved in cisplatin toxicity. The mitochondrion is the primary target for cisplatin induced oxidative stress, ... Dimethylthiourea protects against mitochondrial oxidative damage induced by cisplatin in liver of rats. Chem.Biol.Interact. 2007; 170:177–186. [Google Scholar]
Cisplatin liver toxicity
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WebFeb 2, 2024 · The liver is an important central organ for metabolism and detoxification in the human body and is susceptible to many factors, such as excessive alcohol consumption, hepatoviruses, various toxins, and drugs, leading to the development of liver diseases. ... Toxicity of Cisplatin to the central Nervous System of Male Rabbits. Bter 74 (3), 223 ... WebAn association between cisplatin administration and hepatotoxicity is proposed in this patient. Conclusions: This patient may have experienced cisplatin-induced liver …
WebCisplatin (CP) is a potent and extensively used chemotherapeutic agent. There is paucity of literature involving role of mitochondria in mediating CP-induced hepatic toxicity, and its underlying mechanism remains unclear. Oxidative stress is a well-established biomarker of the mitochondrial toxicity. WebNov 12, 2024 · Nephrotoxicity: cisplatin injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Consider dose reductions or alternative treatments in patients with renal impairment. Peripheral Neuropathy: cisplatin injection can cause dose-related peripheral neuropathy.
WebIts stereoisomer transplatin does not have any toxicity at equimolar concentrations, and it also possesses little antitumor activity. In this study, subcellular localization of both the platinum isomers was examined in the liver and kidney of the mouse 24 hours following the drug administration. WebFeb 16, 2024 · NEPHROTOXICITY: This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure …
WebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically …
WebJul 15, 2024 · Hepatotoxicity can manifest in many different ways ranging from acute, transient elevations in LFTs such as bilirubin or liver enzymes to long term complications such as cirrhosis or liver failure if liver damage progresses unnoticed . Thus, proper recognition of patients at risk for hepatotoxicity before anticancer treatment is started and ... cumberland beanWebJan 18, 2024 · Cisplatin resistance, which often results in disease recurrence, originates from multiple cellular self-defence adaptations, including reduced uptake and increased drug efflux, inactivation by... cumberland bird of prey centre thursonfieldWebPaclitaxel, Ifosfamide and Cisplatin Regimen is Feasible for —文档、资料、论文、办公、总结,均是精品资料,免费阅读,免费分享,值得下载! east playgroundeast playWebJun 21, 2024 · Hepatoblastoma is a rare primary liver cancer with an age-adjusted incidence of 0.13 patients per 100,000 population. 1 Hepatoblastoma can be categorized as standard-risk or high-risk disease... cumberland bike trail trainWebMar 9, 2024 · Cisplatin mediates nephrotoxicity via a number of different cytotoxic mechanisms. In addition to DNA damage, cisplatin also causes cytoplasmic organelle dysfunction, particularly in the endoplasmic reticulum and mitochondria, activates apoptotic pathways, and inflicts cellular damage via oxidative stress and inflammation [6]. east playersWebAlong with CIN, cisplatin-induced liver toxicity is also associated with NLRP3 inflammasome activity, though this is far less studied. Cisplatin-treated rat liver has … cumberland bitcoin