WebThe US Food and Drug Administration has issued a warning that omeprazole (Prilosec) reduces the antiplatelet activity of clopidogrel (Plavix) by about 50%. However, the … WebResults: We observed a significant reduction in clopidogrel's effect when patients were initiated with omeprazole; the mean P2Y12 reaction units (PRU) increased from 202±52 to 235±58 with omeprazole (P<0.001). With pantoprazole, clopidogrel efficacy was preserved (PRU 215±54, P=0.16).
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WebMar 30, 2024 · Wedemeyer RS, Blume H. Pharmacokinetic drug interaction profiles of proton pump inhibitors: an update. Drug Saf. 2014 Apr;37(4):201-11. doi: 10.1007/s40264-014-0144-0. WebMay 26, 2024 · The interaction between Plavix (clopidogrel), an antiplatelet drug and omeprazole, a proton pump inhibitor, is one of the more well-known interactions to clinicians. While we appear to not fully understand the complete mechanism behind the … greensboro county nc
FDA Drug Safety Communication: Reduced effectiveness of Plavix ...
WebApr 9, 2024 · Two large studies addressed the interaction between clopidogrel and a variety of proton pump inhibitors 2, 3. These studies demonstrated an interaction between clopidogrel and omeprazole and suggested an interaction between clopidogrel and rabeprazole or lansoprazole. WebJul 1, 2010 · NEW ORLEANS — Adverse effects attributed to proton pump inhibitors, including a risk for adverse interactions with clopidogrel, have probably been overstated. Dr. Michael F. Vaezi, professor of medicine and clinical director of the division of gastroenterology at Vanderbilt University Medical Center in Nashville, Tenn., told … WebNov 17, 2009 · The studies show that omeprazole and esomeprazole—both members of a class of stomach acid-reducing drugs called proton pump inhibitors, or PPIs—can lower the effectiveness of Plavix , putting ... fm 35 royse city texas