Cyclic pifithrin-a

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August undefined, 2024

WebJul 1, 2008 · In this study, we used cyclic pifithrin-α, a transcriptional inhibitor of p53, to further investigate the relevance of p53 function in the response of tumor cells to … WebCyclic pifithrin-alpha-p-nitro, transcriptional p53 inhibitor(PFT-α) 是一种 p53 的灭活剂，可阻断 p53 依赖性转录激活和细胞凋亡。 Cyclic PFT-α 是 PFT-α 的稳定类似物。 p-nitro-Cyclic PFT-α 是一种可渗透细胞的环状 PFT-α。在保护暴露于依托泊苷 (ED50 = 30 nM) 的皮质神经元方面，它比 ...

Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to

WebCyclic Pifithrin-alpha Hydrobromide 98.0 %, TCI America Fisher Scientific Fisher Scientific Fisher Healthcare Fisher Science Education Sign Up for Email Help & Support … Webp-nitro-Cyclic Pifithrin-α 市场价￥1,339.80 好评率 100% (0)条评论商城价登录后可查看价格 diversus psychiatry

Cyclic Pifithrin-α Sensitizes Wild Type p53 Tumor Cells to ...

WebKey features and details. Cell-permeable transcriptional p53 inhibitor. CAS Number: 60477-38-5. Purity: > 99%. Soluble in DMSO to 10 mM. Form / State: Solid. WebCyclic analog of pifithrin-α, a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50= 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents. WebNov 7, 2005 · Cells were incubated with or without 10 μg/ml CCN1 for 6 h and immunostained and scored for activated Bax. (B) Cells were transfected with either the pBabePuro vector or the same vector expressing GSE56, or were pretreated with 200 μM of cyclic pifithrin for 1 h. Cells were incubated with or without 10 μg/ml CCN1 for 24 h and … cradle swapping dvd

p-nitro-Cyclic Pifithrin-α (CAS 60477-38-5) - caymanchem.com

WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine … WebApr 1, 2005 · Cyclicpifithrin-α, a well-characterized small-molecule inhibitor of p53-dependent transactivation of p53-responsive genes, was used as positive control (33). Together, these results suggest that... cradle swings for big babiesWebThe yellow region in helix 1 is the MRAIL sequence or hydrophobic patch, which contributes to the recognition of some substrates. (PDB 1fin) Cyclin is a family of proteins that … cradle swings fisher price

"WebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. Packaging 5, 10 mg in glass bottle Protect from light. Biochem/physiol Actions A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity. " - Cyclic pifithrin-a

Cyclic pifithrin-a

Pifithrin-α, p-Nitro, Cyclic (PFN-α) p53 Inhibitor MedChemExpress

WebJul 17, 2024 · Cell-based assays in multiwell plates are widely used for radiosensitivity and chemosensitivity assessment with different mammalian cell types. Despite their relative ease of performance, such assays lack specificity as they do not distinguish between the cytostatic (reversible/sustained growth arrest) and cytotoxic (loss of viability) effects of … WebCyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis Authors Valentina Zuco 1 , Franco Zunino Affiliation 1 Department of Experimental Oncology and Laboratories, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy. PMID: 18516295 PMCID: PMC2386543 DOI: 10.1593/neo.08262 …

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WebCyclic PFT-α was a stable analog of PFT-α. p-nitro-Cyclic PFT-α, a cell-permeable form of cyclic PFT-α, was found to be one order of magnitude more active than PFT-α in protecting cortical neurons exposed to etoposide. p-nitro-Cyclic PFT-α acted in a p53-dependently but did not block phosphorylation of p53 on Ser15 in response to etoposide … WebJan 11, 2024 · Select the department you want to search in ...

WebJul 1, 2008 · (PDF) Cyclic Pifithrin-α Sensitizes Wild Type p53 Tumor Cells to Antimicrotubule Agent–Induced Apoptosis 1 Cyclic Pifithrin-α Sensitizes Wild Type p53 Tumor Cells to Antimicrotubule... WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α a small molecule inhibitor of p53. It reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis, with less cytotoxicity than the parent compound. Potent STAT6 transcriptional inhibitor.

WebPifithrin-α is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. Pifithrin-α enhances …

WebPifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α. - Find …

WebCyclic Pifithrin-α (hydrobromide) from Cayman Chemical. Be the first to write a review! Citations: Description A stable analog of PFT-α, formed by the condensation of PFT-α in solution; inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC50 = 23, 77, and 103 µM, respectively); induces autophagy in HCT116 cells and ... cradle swing fisher price butterflyWebCyclic Pifithrin-α hydrobromide. Synonym(s): 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide, Cyclic PFT-α hydrobromide, Pifithrin-α, cyclic, QB102. Empirical Formula (Hill Notation): C 16 H 16 N 2 S · HBr. CAS No.: 511296-88-1. Molecular Weight: 349.29. Compare Product No. Description SDS Pricing; P4236: cradle technologiesWebPifithrin-α, p-nitro, cyclic Pifithrin-α, p-nitro, cyclic is A cell-permeable p53 inhibitor that is more potent & has a longer half-life than Pifithrin-α. 60477-38-5 sc-222177 sc-222177A sc-222177B sc-222177C : 5 mg 10 mg 25 mg 50 mg: $164.00 $300.00 $600.00 1 cradle swing my little lamb