WebJun 1, 2004 · CYP2E1 and CYP4A11 are cytochrome P450 enzymes that are regulated by physiological conditions including diabetes and fasting. In addition, the xenochemical clofibrate has been reported to induce both rodent CYP2E1 and CYP4A. These findings suggest similar modes of regulation. WebDec 20, 2024 · MCE (MedChemExpress) 是全球领先的科研化学品和生物活性化合物供应商。提供 25000 多种特异性抑制剂作用于 20 个信号通路的 375 个靶点蛋白,疾病研究领域。
CYP4A11 cytochrome P450 family 4 subfamily A member …
WebCYP4A11 INFORMATION. Proteini. Full gene name according to HGNC. Cytochrome P450 family 4 subfamily A member 11. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. CYP4A11 (CYP4A2, CYP4AII) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). WebThe cytochrome P450 (CYP) is a monooxidase, which regulates metabolism of drugs and fatty acids in the liver and kidney. Among isoforms of the CYP4A subfamily, CYP4A11 is a major lauric acid (medium-length fatty acids) omega hydroxylase and is involved in the balance of lipids in the human liver. inclined towards nursing
Liver Microsomes, S9 Fractions and Cytosol - Thermo Fisher Scientific
WebFeb 12, 2012 · CYP4A11 genotype did not affect pressor responses to Angiotensin II in normotensive or hypertensive individuals. The loss-of-function CYP4A11 8590C allele is associated with a diagnosis of ... WebJan 1, 2003 · HepG2 cells that stably overexpress PPARα were used to examine the regulation of the two known human CYP4A genes by Wy14643. Specific PCR amplification across intron 5 and restriction endonuclease analysis indicated that HepG2 cells possess genes corresponding to both the CYP4A11 cDNA and a more recently characterized … WebImmunocytochemistry showed CYP4F2 and CYP4A11 expression in only the S2 and S3 segments of proximal tubules in cortex and outer medulla. Our results demonstrate that CYP4F2 and CYP4A11 underlie conversion of AA to 20-HETE, a natriuretic and vasoactive eicosanoid, in human kidney. Considering their proximal tubular localization, these P450 ... inclined top