Webthis study identified growth differentiation factor 5 (GDF5) was a direct target gene of miR-665 in nucleus pulposus cell and enforced expression of miR-665 decreased GDF5 expression. GDF5 rs143383 polymorphism was significantly associated with susceptibility to intervertebral disc degeneration and osteoarthritis. (Meta-analysis) WebGrowth differentiation factor 5 (GDF5) gene is located on the chromosome 20q11.2 and it regulates the expression of GDF5 protein. It is classified within the bone morphogenetic protein group (BMP) . It …

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WebSep 25, 2024 · Growth differentiation factor 5 (GDF5) was reported to regulate brown adipogenesis; however, its effects on insulin sensitivity, full metabolic syndrome … WebGDF5 could improve insulin sensitivity and prevent metabolic syndrome, the adaptive thermogenesis in sWAT could mediate the obesity resistance effects of GDF5 in mice and partially resulted in the activation of the p38 MAPK signaling pathway. Growth differentiation factor 5 (GDF5) was reported to regulate brown adipogenesis; however, … WebAlthough growth differentiation factor-5 (GDF5) has been implicated in skeletal development and joint morphogenesis in mammals, little is known about its functionality in … adozione mite significato