Griffithsin virus patent

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August undefined, 2024

WebOct 6, 2024 · Virus entry into a susceptible host cell is the first step in the formation of all viral diseases. Controlling viral infections by disrupting viral entry is advantageous for antibody-mediated neutralization by the host’s immune system and as a preventive and therapeutic antiviral strategy. Recently, several plant-derived carbohydrate-binding … WebCDC tested a broad-spectrum antiviral from a protein found in red alga, Griffitshia sp., that offers a low-cost way to potentially prevent or treat infections from rabies virus. Researchers determined that Griffithsin (GRFT) neutralizes rabies virus (RABV) activity in vitro and in vivo. Currently, with the exception of RIG and another ...

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WebFeb 7, 2011 · US Patent for Griffithsin, glycosylation-resistant griffithsin, and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of use Patent (Patent # 8,394,764 issued March 12, 2013) - Justia Patents Search WebDec 1, 2006 · US Patent for Anti-viral griffithsin compounds, compositions and methods of use Patent (Patent # 8,088,729 issued January 3, 2012) - Justia Patents Search Anti-viral griffithsin compounds, compositions and methods of use Dec 1, 2006 - The United States of America as represented by the Secretary, Department of Health and Human Services name two hormonal methods of contraception

Griffithsin, a potent HIV entry inhibitor, is an excellent candidate ...

WebThis technology describes the lectin, Griffithsin (GRFT), isolated from red algae. GRFT shows significant broad-spectrum anti-viral activity making it a promising agent for use as … WebThe invention relates to an anti-viral Griffithsin polypep tide related conjugates, compositions, nucleic acids, vectors, host cells, antibodies, and methods for their production and SC. BACKGROUND OF THE INVENTION WebFeb 10, 2016 · Justia Patents US Patent for Griffithsin mutants Patent (Patent # 10,501,507) Griffithsin mutants . Feb 10, 2016 - ... invention provides an antiviral … name two highlights of constructivism

Griffithsin tandemers: flexible and potent lectin inhibitors of the ...

Griffithsin virus patent

Safety and Acceptability of Q GRFT Nasal Spray for COVID-19 …

WebJan 23, 2015 · The lectin griffithsin (GRFT) is a potent antiviral agent capable of prevention and treatment of infections caused by a number of enveloped viruses and is currently … WebJul 8, 2024 · In addition, Griffithsin could be used in combination with other anti-viral agents to treat patients who have drug-resistant virus. A related NCI invention, reference …

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WebJul 19, 2024 · Griffithsin works by binding to viruses, preventing them from infecting cells in both animals and humans. “The nice thing about Q-griffithsin is that it has a number of activities against other... WebOn December 1, 2006, the patent was filed and granted – U.S. Patent #US 8088729 B2. The interesting thing here is that the inventors of the patent are listed as: Barry O’Keefe, …

WebGriffithsin is a mixed specificity lectin, belonging to the Jacalin Lectin family, which binds mannose, glucose, and N-acetylglucosamine. ... Perhaps the greatest biological application of GRFT is as a microbicide for Human Immunodeficiency Virus type-1(HIV-1). GRFT’s antiviral properties arise from its ability to bind to glycoproteins on the ... Webplants transduced with a tobacco mosaic virus vector expressing GRFT. Plant-produced GRFT (GRFT-P) was shown as active against ... the red algal protein griffithsin (GRFT) …

WebMay 11, 2024 · 1 Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. 2 Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA. WebAug 2, 2011 · Many natural product-derived lectins such as the red algal lectin griffithsin (GRFT) have potent in vitro activity against viruses that display dense clusters of …

WebDec 9, 2024 · The University of Louisville has received funding from the U.S. Department of Defense (DoD) to develop a nasal spray to prevent serious viral respiratory infections such as COVID-19 using...

WebUS10501507B2 US15/550,323 US201615550323A US10501507B2 US 10501507 B2 US10501507 B2 US 10501507B2 US 201615550323 A US201615550323 A US 201615550323A US 10501507 B2 US10501507 B2 megamax container shipWebNov 16, 2024 · Q-Griffithsin (Q-GRFT) nasal spray is an investigational product that has broad spectrum antiviral activity. Q-GRFT is derived from Griffithsin (GRFT) a naturally occurring protein originally isolated from the red alga Griffithsia found in the South Pacific Ocean. For the purposes of this study GRFT has been genetically modified to produce a ... name two ingredients in 5w30 maxlifeWebGriffithsin, a potent HIV entry inhibitor, is an excellent candidate for anti-HIV microbicide The in vitro efficacy of GRFT revealed low cytotoxicity, high potency, rapid onset of antiviral activity and long-term stability in cervical/vaginal lavage. GRFT is an excellent candidate for anti-HIV microbicide development. megamax in publicWebgriffithsin seq hiv vector virus Prior art date 2015-02-10 Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and … mega maxillary antrostomyWebDec 16, 2010 · Background Griffithsin, a 121-residue protein isolated from a red algal Griffithsia sp., binds high mannose N-linked glycans of virus surface glycoproteins with extremely high affinity, a property that allows it to prevent the entry of primary isolates and laboratory strains of T- and M-tropic HIV-1. We used the sequence of a portion of … name two harvest festival of indiaWebOct 6, 2024 · Griffithsin, a Highly Potent Broad-Spectrum Antiviral Lectin from Red Algae: From Discovery to Clinical Application Mar Drugs. 2024 Oct 6;17(10):567.doi: 10.3390/md17100567. Author Choongho Lee 1 Affiliation 1College of Pharmacy, Dongguk University, Goyang 10326, Korea. [email protected]. PMID: name two hills of gujaratWebIn particular, a red algae-derived griffithsin (GRFT) protein has demonstrated superior in vitro and in vivo antiviral activity with minimum host toxicity against a variety of clinically relevant, enveloped viruses. This review examines the structural characteristics of GRFT, focusing on its carbohydrate-binding capability. megamax twitter