Inthomycin
WebOct 19, 2010 · The synthetic utility of this methodology was demonstrated in the first short synthesis of naturally occurring inthomycin C in high enantiopurity. A cationic oxazaborolidinium-catalyzed asymmetric Mukaiyama aldol reaction of (1-methoxy-2-methyl-propenyloxy)-trimethylsilane with various aldehydes including α,β-disubstituted acroleins … WebThe total syntheses of (+)-inthomycin A, (+)-inthomycin B and (−)-inthomycin C, the oxazole-triene antibiotics isolated from Streptomyces sp., have been accomplished via …
Inthomycin
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WebThe quantification of inthomycin B demonstrated that Streptomyces sp. YB104 produced moderate yield of inthomycin B with a yield around 25 mg/l after 14 days. Thus, Streptomyces sp. YB104 was considered to be a useful potential as a first industrial-producing strain of inthomycins. WebSep 15, 2010 · Phthoxazolin A was first isolated from Streptomyces sp. OM-5714 in 1990 by the group of Omura [].Named inthomycin A, the same compound was isolated independently from Streptomyces strain Gö2 together with the isomers inthomycin B and inthomycin C [].Subsequently, naturally occurring hydroxylated derivatives were …
WebMolecular Formula CHNO. Average mass 290.358 Da. Monoisotopic mass 290.163055 Da. ChemSpider ID 28285231. - Double-bond stereo. - 1 of 1 defined stereocentres. WebJun 24, 2014 · A new pathway to (+)-inthomycin C is reported that exploits an O-directed free radical hydrostannation reaction on chiral alkyne and a Stille cross-coupling as key steps. Our stereochemical studies confirm that Ryu and Hatakeyama’s (3S)-stereochemical revision of (+)-inthomycin C is invalid and that Zeeck and Taylor’s original (3R) …
Websette. Wang et al. 16] described that the inthomycin B and its two new analogues were isolated from the crude extract of Streptomyces pactum L8. Combined with the gene deletion of the rare P450 domain in the NRPS module, a formation mechanism of carboxamide moiety in inthomycins was pro-posed via an oxidative release of the … WebOct 19, 2024 · The isolation of inthomycin A was first reported by Ōmura in 1990 1 who subsequently reported the isolation of inthomycins B and C in 1995. 2 Between these …
WebThis procedure has been utilised to prepare (+)-inthomycin B and (+)-inthomycin C for the first time; in these examples the stereogenic centre was introduced using the Kiyooka ketene acetal/amino acid-derived oxazaborolidinone variant of …
WebA novel total synthesis of inthomycin C has been accomplished in 11.4% yield and 89% ee over ten linear steps from oxazole. This synthesis is the shortest and highest yielding … tiffany maldonado shsuWebVita. 2024. since June: Head of an Independent Lise Meitner Research Group at the Max-Planck-Institut für Kohlenforschung, Mülheim an der Ruhr, Germany. 2024 - 2024. Postdoctoral Research Associate at Massachusetts Institute of Technology, Cambridge, USA with Prof. Mircea Dincă. 2016 - 2024. the meadows at elkWebSep 1, 2024 · Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain. Inthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8.Identification of the gene cluster for inthomycin biosynthesis as well as the 15 N-labeled glycine incorporation into … the meadows at cascade parkWebSep 1, 2024 · Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain. Inthomycin B (1) and its two new analogues 2 and 3 were … the meadows at elk creekWebNational Center for Biotechnology Information the meadows at brier creek apartmentsWebMay 19, 2008 · The inthomycins have been shown to be highly specific inhibitors of cellulose biosynthesis, displaying selective in vitro antimicrobial activity against Phytophtora … the meadows at dahlgrenWebThis article is cited by 16 publications. Daozhong Zhang, Zhijun Tang, Wen Liu. Biosynthesis of Lincosamide Antibiotics: Reactions Associated with Degradation and Detoxification … tiffany malaysia price