Klf5 phosphorylation

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August undefined, 2024

WebJan 12, 2024 · Here, we identified a YAP1 tyrosine phosphorylation-dependent YAP1-KLF5 oncogenic module, as the key downstream mediator of SRC kinase regulating cancer stemness and metastasis in triple-negative breast cancer (TNBC). SRC was overexpressed in TNBC patient tissues and its expression level was highly correlated with the tumor … WebVarious KLFs, including KLF5, are involved in cancer-related processes, such as epithelial-mesenchymal transition (EMT), invasion, and metastasis (3-6). In addition, studies show …

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WebMar 8, 2011 · Phosphorylation of HDAC2 switches its interaction preference from RAR to Klf5, and thus promotes Klf5 deacetylation. Deacetylated Klf5 then dissociates from the p21 promoter, and the... WebNov 16, 2012 · Abstract 2313. Krüppel-like factor 5 (KLF5) is a member of a highly conserved group of transcription factors (the KLF family) that have regulatory roles in … pm0214 programming manual for cortex-m4

Metformin suppresses triple-negative breast cancer stem cells by ...

WebMay 10, 2024 · PRMT5 and KLF5 protein levels were positively correlated in clinical BLBCs. Taken together, PRMT5 methylates KLF5 to prevent its phosphorylation, ubiquitination, and degradation, and thus... WebDec 6, 2024 · Moreover, we tested the klf5 phosphorylation level as well, the result demonstrated that high-fat diet decreased the klf5 phosphorylation level, whereas RSV … WebApr 11, 2024 · SPI1, HIF1A, STAT1, KLF5, RUNX1, MBD1, SP1, and WT1 may be involved in the regulatory mechanisms of DN development. Our study may provide a potential biomarker or therapeutic locus for the study of DN. ... (Zhang et al., 2024c), STAT1 phosphorylation inhibited the M1 phenotypic transformation of macrophages and suppressed DN … pm05 salary government

Synthetic retinoid Am80 inhibits interaction of KLF5 with RARα …

WebApr 14, 2024 · Enhancer RNAs (eRNAs) are non-coding RNAs (ncRNAs) transcribed in enhancer regions. They play an important role in transcriptional regulation, mainly during cellular differentiation. eRNAs are tightly tissue- and cell-type specific and are induced by specific stimuli, activating promoters of target genes in turn. eRNAs usually have a very … WebFeb 1, 2024 · KLF5 inhibition holds therapeutic potential for cardiovascular diseases. Abstract Krüppel-like factors (KLFs) are DNA-binding transcriptional factors, which regulate various pathways that pertain to development, metabolism and other cellular mechanisms. KLF5 was first cloned in 1993 and by 1999, it was reported as the intestinal-enriched KLF. pm01 convention collective bereavement payWebDec 28, 2009 · KLF5 is a downstream signal of the ERK 1/2 and p38 MAPK pathways, and activates the transcription of cyclin D1 gene via functional interaction with c-Jun in Ang II-induced VSMC proliferation. Keywords: Krüppel-like factor 5, cyclin D1, angiotensin II, proliferation, vascular smooth muscle cells Go to: Introduction pm0106507 powermate generator parts

"WebJul 23, 2009 · To understand whether the change in KLF5 phosphorylation is responsible for the increased interaction between KLF5 and c-Jun, we detected the levels of phospho-KLF5 in VSMCs treated with Ang II. As shown in Fig. 3 A, Ang II stimulation rapidly induced phosphorylation of KLF5 within 0.5 h, and KLF5 phosphorylation reached the maximum at … " - Klf5 phosphorylation

Klf5 phosphorylation

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WebJan 13, 2024 · Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer. 10 … WebFeb 1, 2024 · Resveratrol induced KLF5 phosphorylation in renal HEK293 cells and prevented association of KLF5 with c-Myc. 25 Moreover, KLF5 phosphorylation could modulate its activation status as KLF5-Ser153 phosphorylation by protein kinase C at the CREB binding protein (CBP) interaction site promoted its transactivation function in …

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WebKrüppel-like factor 5 (KLF5) is an oncogenic factor that is highly expressed in basal-like breast cancer (BLBC) and promotes cell proliferation, survival, migration, stemness, and tumor growth; however, its posttranslational modifications are poorly defined. WebApr 17, 2009 · Protein phosphorylation has been an important mechanism by which a transcription activator recruits coactivators, such as phosphorylation of cAMP response element-binding protein (CREB) at Ser133 leading to the recruitment of CREB-binding protein (CBP) [23], phosphorylation of KLF5 at the CBP interaction region enhancing its …

WebApr 4, 2024 · correlation between the KLF5 and ZEB1 transcription levels in the pancreatic tumor tissues The present study has identified that KLF5, a target of miR-145-5p, is a key … WebDec 10, 2013 · Phosphorylation of KLF5 on serine 406 also enhances interaction with unliganded RARα, which binds to the first zinc finger of the KLF5 DBD, to activate downstream target genes 90, 93. RAR agonists are thought to act via two mechanisms to disrupt the interaction between KLF5 and RARα and subsequently inhibit VSMC …

WebJul 12, 2024 · These results indicate that LFU and microbubbles combined with simvastatin downregulates the expression of YAP and RHAMM, upregulates LATS1 expression and promotes the phosphorylation of YAP in MCF-7 cells. KLF5, a downstream protein of YAP, had the lowest expression in the UM+SIM group (Fig. 4A). WebDec 28, 2009 · For this, the phosphorylation status of KLF5 was tested via cross-immunoprecipitation using anti-phospho-Ser and anti-KLF5 antibodies. As shown in Figure 3A, Ang II effectively increased the...

WebOct 11, 2024 · HDAC2 phosphorylation-dependent Klf5 deacetylation and RARalpha acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. The present study provides direct evidence that BTEB2 plays a critical role in balloon injury-induced neointimal hyperplasia, which is closely linked to vascular SMC …

WebDec 6, 2024 · Furthermore, we detected the levels of klf5 phosphorylation, suggesting klf5 phosphorylation level in HFD group was lower than HFD+RSV group. In parallel, in HEK293 cells, we also observed that HG (25 mmol/L) enhanced the interaction of klf5 with c-Myc and klf5 dephosphorylation, which were reversed by treatment with inhibitor LY294002 and RSV. pm0916-whWebMar 30, 2024 · EMT played an important role in platinum resistance, while oxidative phosphorylation is the opposite. There was a small subset of cells in platinum-sensitive samples which had transcriptomic characteristics similar to platinum-resistant cells, suggesting that the progression of platinum resistance in ovarian cancer is inevitable. pm1 salary government of canadaWebDec 1, 2010 · Klf5 –/– embryos showed no expression of Eomes (C) or Krt8 (D). (E) Normal FGF-RTK-MAP kinase signaling in Klf5 –/– embryos. Phosphorylation (P) of ERK (p44/42 MAPK, also known as Erk1/2 and Mapk3/1) was at similar levels in control and mutant embryos. No background staining was detected in the absence of pERK antibodies. pm1 standoffWebTriple-negative breast cancer (TNBC) is the most lethal form of breast cancer. Lacking effective therapeutic options hinders treatment of TNBC. Here, we show that bepridil (BPD) and trifluoperazine (TFP), which are FDA-approved drugs for treatment of pm0525202 coleman powermate manualWebJul 2, 2007 · KLF5 loss specifically resulted in reduced Bad phosphorylation at both ser112 and ser136 residues. Densitometric analysis confirmed that reduced Bad phosphorylation was significant across... pm1 wheatWebKLF5 is a member of the Kruppel-like factor subfamily of zinc finger proteins. It contains three C2H2-type zinc fingers at the carboxyl-terminus that preferentially bind to cis-DNA … pm1001 sophiaWeb目的探讨锌指转录因子Krüppel样因子5(Krüppel-like factor 5,KLF5)在高糖诱导的血管平滑肌细胞(vascular smooth muscle cells,VSMCs)炎症中的作用及机制.方法体外培养VSMCs,实时定量反转录聚合酶链反应(quantitative real-time polymerase chain reaction,qRT-PCR)、蛋白 … pm100d thorlabs driver