Malat1 microglia

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August undefined, 2024

WebJul 1, 2024 · Long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) was widely recognized to be implicated in human cancer, vascular diseases, and neurological disorders. This study was to explore the role and underlying mechanism of MALAT1 in acute spinal cord injury (ASCI). WebJul 1, 2024 · We hypothesized that MALAT1 was involved in the LPS-induced activation of microglial cells and proinflammatory cytokine production. MALAT1 was inhibited in the LPS-activated microglia cells BV2 and N9 in vitro by mean of transfection of siRNA-MALAT1 ( …

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WebApr 14, 2024 · Humans are often simultaneously exposed to benzo(a)pyrene (BaP) and dibutyl phthalate (DBP) through consumption of food and water.Yet, direct evidence of … WebApr 14, 2024 · Much of Dr. Haney's work focuses on diseases of the aging brain, such as Alzheimer’s disease, with a particular focus on neuroimmunology and the reaction that … bata pe

The METTL3/MALAT1/PTBP1/USP8/TAK1 axis promotes …

WebFeb 19, 2024 · Systemic sclerosis (SSc) is an autoimmune disease with completely undefined etiology and treatment difficulties. The expression of both protein coding and non-coding RNAs is dysregulated during disease development. We aimed to examine a possible regulatory axis implemented in the control of chitinase-3 like protein 1 (CHI3L1) or YKL … WebMar 6, 2024 · The present study aimed to verify whether long noncoding RNA (lncRNA) MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and to explore the mechanism by which MALAT1 regulates aquaporin 4 (AQP4). In this study, we established glucose deprivation (OGD)/reoxygenation (RX) astrocyte cell model and … WebApr 5, 2024 · GAS5 is able to prohibit microglial M2 polarization via blocking TRF4 transcription. LincRNA-p21 can induce the activation of microglia via a p53-dependent transcriptional pathway. Additionally, lncRNA MALAT1 is involved in astrocyte apoptosis and neurodegeneration through alternative splicing of PKC δII and CREB signaling pathway. bata perú

MALAT1 - an overview ScienceDirect Topics

Malat1 microglia

The lncRNA Malat1 functions as a ceRNA to contribute …

WebMALAT1 Mediates α -Synuclein Expression through miR-23b-3p to Induce Autophagic Impairment and the Inflammatory Response in Microglia to Promote Apoptosis in Dopaminergic Neuronal Cells Table 1 RT-qPCR primer sequences. WebOct 11, 2024 · Microglia/macrophages (MMs) are the first line of defense against central nervous system (CNS) injuries, and they function as a key participant in maintaining brain homeostasis. The resident microglia and peripheral macrophages are rapidly activated after cerebral ischemia ( Perego et al., 2011 ).

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WebMar 15, 2024 · MALAT1 (metastasis associated lung adenocarcinoma transcript 1) is a lncRNA which is present within cell nuclei and is known to regulate the expression of various genes by organizing ribonucleoprotein complexes and influencing RNA transcription and maturation (Eissmann et al., 2012 ). WebAug 12, 2024 · MALAT1 inhibits the expression of Nrf2 by epigenetic means, thus promoting microglial inflammation, leading to M1/M2 imbalance and aggravating nerve damage in PD ( 32 ). In patients with MS, the expression of MALAT1 is significantly down-regulated.

WebApr 6, 2024 · MALAT1 can promote α -synuclein expression by regulating miR-23b-3p, thereby inducing microglial autophagy disorder and an inflammatory response leading to apoptosis of dopaminergic neurons. This newly discovered molecular mechanism may provide a potential target for the treatment of PD. ... In addition, microglia produce a … WebApr 14, 2024 · Humans are often simultaneously exposed to benzo(a)pyrene (BaP) and dibutyl phthalate (DBP) through consumption of food and water.Yet, direct evidence of the link between BaP and DBP co-exposure and the risk of splenic injury is lacking.

WebNov 10, 2024 · In the current study, microglia were transfected with siRNA-MALAT1, pcDNA-MALAT1 or miR-199b mimic/inhibitor and 6 h later stimulated with 100 ng/ml … WebDec 24, 2024 · Malat1 is a ubiquitously expressed long non-coding RNA that localizes in the nucleus and has previously been used to study the organ and cell type activity of ASOs …

WebAug 27, 2024 · Finally, we demonstrated that MALAT1 acts as a competing endogenous RNA by directly binding to miR-124 to regulate AGA-induced MCP-1 expression in …

WebMar 21, 2024 · Entrez Gene Summary for MALAT1 Gene. This gene produces a precursor transcript from which a long non-coding RNA is derived by RNase P cleavage of a tRNA-like small ncRNA (known as mascRNA) from its 3' end. The resultant mature transcript lacks a canonical poly (A) tail but is instead stabilized by a 3' triple helical structure. tanjiro gifs cuteWebMay 9, 2016 · Interaction of malignant glioma cells and microglia. Schematic summary of experimental data revealed that malignant brain tumors secrete the cytokine MIF, which activates the CD74 receptor on ... tanjiro gifsWebApr 3, 2024 · We found that knockdown of MALAT1 ameliorated neurological deficits, encephaledema, and pyroptosis in vivo and restored microglia cell function in vitro. … tanjiro gif sadWebJun 1, 2024 · Microglia consistently maintain the homeostasis of the central nervous system (CNS) parenchyma by monitoring for injuries or pathological changes. 1 However, once … bata peru rucWebMALAT1, originally identified in pulmonary adenocarcinoma, is among the most abundant lncRNA in the nervous system. It is described as heavily expressed in different types of … bata perugiaWebCompound. Class. Types of study. Cell line(s)/animal(s) model(s). Neurological disorders. Mechanism of action. References.; Luteolin: In vitro: Rat adrenal pheochromocytoma cell (PC12) bata peru empresaWebAug 20, 2024 · Malat1 was initially found to be upregulated in various tumor tissues and was thought to participate in the development and metastasis of cancer [ 14 ]. Subsequently, a clinical study demonstrated that Malat1 was highly expressed in ischemic stroke patients among the 20 studied lncRNAs [ 15 ]. bata perú ruc