Rbfox2是什么
WebFeb 27, 2014 · Here, we have used several established cell culture models to investigate the functions of Rbfox2 during EMT. We demonstrate that induction of an EMT upregulates … WebRBFOX2-Binding Sites Are Enriched in Pre-mRNAs that Undergo AS Changes in Diabetic Hearts We have previously identified genome-wide AS changes in type 1 diabetic (T1D) mouse hearts with a corresponding in-crease in RBFOX2 protein levels (Verma et al., 2013). Therefore, we hypothesized that RBFOX2 is involved in AS dysregulation in diabetic hearts.
Rbfox2是什么
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WebFeb 25, 2013 · In both the cell lines, Rbfox2 expression increased moderately, by 1.5–2-fold, following induction of an EMT by TGFβ treatment, suggesting an active function of this …
Web尽管已经有很多研究表明RBFox蛋白在心脏疾病中的作用,但影响RBFox2表达的机制还需深入研究。. 目前,对RBFox蛋白功能与机制的研究多数是借助动物模型或人类病理组织中 … WebRBFOX2 INFORMATION. Proteini. Full gene name according to HGNC. RNA binding fox-1 homolog 2. Gene namei. Official gene symbol, which is typically a short form of the gene …
Rbfox2 is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative splicing in the nervous system and other cell types. Rbfox2 and the related protein Rbfox1 bind to conserved (U)GCAUG RNA motifs in the introns adjacent to many alternatively spliced exons and promotes inclusion or exclusion of the alternative exon in mature transcripts. The protein also interacts with the estrog… WebMay 5, 2024 · Background. Long noncoding RNAs (lncRNAs) play a significant role in the progression and metastasis of various cancers. LINC00893 has been reported to exert antitumor effect on various cancers such as gastric cancer and thyroid cancer. Bioinformatics analysis also predicted that LINC00893 was downregulated in colon …
WebDec 19, 2024 · Paterson and Yu et al. demonstrate that loss of the RNA alternative splicing factor RBFOX2 in the liver during a lipogenic diet leads to dysregulation of liver lipid and cholesterol homeostasis ...
WebVerma SK et al. Rbfox2 function in RNA metabolism is impaired in hypoplastic left heart syndrome patient hearts. Sci Rep 6:30896 (2016). PubMed: 27485310; Cammas A et al. hnRNP A1-mediated translational regulation of the G quadruplex-containing RON receptor tyrosine kinase mRNA linked to tumor progression. Oncotarget 7:16793-805 (2016 cindy feng clinical psychologistWebMay 5, 2024 · The RNA-binding protein RBFOX1 is an important regulator of neuron development and neuronal excitability. Rbfox1 is a dosage-sensitive gene and in both mice and humans, decreased expression of Rbfox1 has been linked to neurodevelopmental disorders. Alternative promoters drive expression of Rbfox1 transcript isoforms that … cindy ferocWebFeb 7, 2024 · INTRODUCTION. The RNA binding protein RBFOX2 has an emerging role in heart diseases ().Low RBFOX2 expression or activity are associated with heart failure and … diabetes typ 1 babyWebRBFOX2 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, RBFOX2 Genome Browser, RBFOX2 References RBFOX2 - Explore an overview of RBFOX2, with a histogram displaying coding mutations, full tabulated details of all associated variants, tissue distribution and any drug resistance data. diabetes typ 1 pathophysiologieWebMar 30, 2024 · Here, we employed both 3’-end and nanopore cDNA sequencing to reveal a previously unrecognized role for RBFOX2 in maintaining alternative polyadenylation (APA) signatures in myoblasts. We found that RBFOX2-mediated APA modulates both mRNA levels and isoform expression of a collection of genes including contractile and … cindy ferry remaxWebsplicing via Rbfox1 and Rbfox2 d Rbfox1 and Rbfox2 regulate hundreds of splicing targets in skeletal muscle d Rbfox1 and Rbfox2 loss produces an active and stable isoform of calpain 3 protease d Autophagy flux is markedly decreased in muscle lacking Rbfox1 and Rbfox2 Authors Ravi K. Singh, Arseniy M. Kolonin, Marta L. Fiorotto, Thomas A ... diabetes typ 1 och typ 2Web4.RBFox2与PRC2相互作用 通过正反向CO-IP实验,作者验证了RBFox2与PRC2复合体多个成员相互作用,同时得到了Pull-down结果的支持。通过RBFox2截短体的构建,原核表达和 … cindy ferro