WebAug 6, 2024 · In the late 1980s, more than a dozen phase I studies analyzed the efficacy of paclitaxel as a single agent. 4-9 Without premedication, hypersensitivity reactions (HSRs) occurred in 25%-30% of patients in these studies and clinical development of paclitaxel was consequently delayed. 3,10 In subsequent trials, 11-16 patients were premedicated with … WebPaclitaxel (Taxol; Bristol-Myers-Squib, Princeton, NJ) is a chemotherapeutic agent commonly used in the treatment of breast, ovarian, and non-small cell lung cancers. Hypersensitivity reactions to paclitaxel occur in 3-30% of treated patients and most frequently manifest as dyspnea, bronchospasm, urticaria, hypotension, and erythematous …
Taxol (paclitaxel) injection label - Food and Drug Administration
WebGuidance on the use of H2 antagonists for the prevention and management of hypersensitivity Page 3 of 8 1. Scope 1.1 This guidance has been developed to advise healthcare professionals on the prevention and management of hypersensitivity reactions to systemic anticancer therapy (SACT) in situations where H 2 WebMay 20, 2024 · Based on these findings, the paclitaxel titration protocol included clearing the priming volume of the tubing — an initial bolus of 20 mL at 999 mL/hour over 1 minute — … marine diesel motor mounts
Premedication strategy for weekly paclitaxel - PubMed
WebBackground: A high incidence of hypersensitivity reactions (HSR) to carboplatin and Taxol is limiting the use of carboplatin and Taxol. Objective: We conducted a 5-year study of all … WebMay 1, 2007 · Hypersensitivity reactions to platinum compounds, such as carboplatin and oxaliplatin, are generally consistent with type 1 IgE-mediated hypersensitivity [7, 8]. Some … WebApr 21, 2024 · Warning. Taxol ® (paclitaxel) should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available. Anaphylaxis and severe hypersensitivity reactions … marine diesel repair in south florida